書誌事項
- タイトル別名
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- Enhanced susceptibility to Fas-mediated apoptosis by interferon-.GAMMA. in an oral squamous cell carcinoma cell line
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抄録
Fas is widely expressed on the cell surface of many normal and neoplastic cells and induces apoptotic cell death in the presence of Fas ligand (FasL) or Fas-agonistic antibody CH11 (Fas-mediated apoptosis) Cancer cells constitutively expressing Fas are generally resistant to Fas-mediatedapoptosis. Recently, it has been reported that interferon-γ(IFN-γ) enhances Fas-mediated apoptosis. An oral squamous cell carcinoma cell line, NA, also constitutively expresses Fas on the plasma membrane and shows low susceptibility to Fas-agonistic antibody-induced apoptosis. This study was conducted to examine the effects of IFN-γ on Fas-mediated apoptosis, the expression of Fas and FasL, and the production of soluble Fas (sFas) in NA cells. The results revealed that a Fas-agonistic antibody, CH11, induced apoptosis of NA cells and IFN-γ enhanced susceptibility of NA cells to CH11-induced apoptosis. Further more, IFN-γ up-regulated Fas expression on NA cells without affecting the expression of FasL. A slight decrease in sFas expression was induced by treatment with IFN-γ. These results suggest that IFN-γ may enhance the susceptibility of NA cells to Fas-mediated apoptosis through the up-regulation of Fas.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 50 (11), 629-635, 2004
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206533741824
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- NII論文ID
- 10018618714
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可