抗凝固療法のもとに抜歯術を行った先天性プロテインS欠乏症の1例 Teeth extraction with anticoagulation therapy in a patient with protein S deficiency

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Protein S deficiency is associated with multiple thrombosis resulted from a decrease in vitamin-K dependent protein S. Surgical treatment of patients with this condition requires anticoagulant control with heparin and warfarin potassium.<BR>We report a case of protein S deficiency who received anticoagulant control with heparin and warfarin potassium during multiple teeth extraction. A 27-year-old woman was referred to our hospital because of dental caries and malocclusion. Her medical history did not include venous thromboembolism, but her mother and sister had protein S defficiency.<BR>Protein S deficiency was diagnosed because free-PS antigen was 50.0%(normal range, 65-135 %) and total-PS antigen was 22.0 %(normal range, 60-150%).<BR>Before extraction of the lower left second premolar and both lower third molars, 10, 000units/day of intravenous heparin and 2.0mg/day of warfarin potassium was administered orally when the activated clotting time (ACT) ranged from 130-150 seconds.<BR>Both upper first premolars and the third molar were also extracted affer oral administration of 2.0mg/day of warfarin potassium.<BR>Our experience suggested that anticoagulant therapy with heparin and warfarin potassium for surgical treatment of patients with protein S deficiency provides an excellent perioperative condition without inducing excessive hemorrhage or thromboembolism.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 50(11), 680-683, 2004-11-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018618906
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00215163
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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