TS-1^【○!R】が著効した顎骨浸潤を伴う下顎歯肉癌の2例 Remarkable regression of lower alveolus and gingival carcinoma by chemotherapy with TS-1 : Report of two cases

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著者

    • 高野 昌士 TAKANO Masashi
    • 北海道大学大学院歯学研究科口腔顎顔面外科学 Department of Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University
    • 小野 貢伸 ONO Mitsunobu
    • 北海道大学大学院歯学研究科口腔顎顔面外科学 Department of Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University
    • 大廣 洋一 OHIRO Yoichi
    • 北海道大学大学院歯学研究科口腔顎顔面外科学 Department of Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University
    • 鄭 漢忠 TEI Kanchu
    • 北海道大学大学院歯学研究科口腔顎顔面外科学 Department of Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University
    • 戸塚 靖則 TOTSUKA Yasunori
    • 北海道大学大学院歯学研究科口腔顎顔面外科学 Department of Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University
    • 進藤 正信 SHINDOH Masanobu
    • 北海道大学大学院歯学研究科口腔病理診断学 Department of Oral Diagnostic Pathology, Graduate School of Dental Medicine, Hokkaido University

抄録

We describe two cases of lower gingival carcinoma deeply invading the mandible that remarkably regressed in response to TS-1 chemotherapy. Patient 1, a 73-year-old woman, presented with hypoesthesia of the right lower lip. Clinical examination revealed an ulcerated lesion with induration in the right lower side of the gingiva. Orthopantomography showed a tumor deeply invading the mandible. Biopsy revealed a well-differentiated squamous cell carcinoma. Electrocardiography showed ischemic heart disease, requiring immediate treatment. She underwent percutaneous transluminal coronary angioplasty (PTCA) before mandiblectomy. Twelve days before the operation, she was given TS-1, because the bone defect worsened despite treatment with UFT during cardiovascular therapy. Patient 2, a 61-year-old woman, presented with an ulcerative lesion in the right lower side of the gingiva. Orthopantomography showed an extensive bone defect in the right side of the mandible. After histopathological diagnosis confirmed squamous cell carcinoma, chemotherapy with TS-1 was started 8 days before the operation. Histopathological findings showed that the tumors in both patients regressed remarkably in response to TS-1.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 50(10), 608-611, 2004-10-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018619116
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00215163
  • データ提供元
    CJP書誌  J-STAGE 
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