TS-1^【○!R】が著効した顎骨浸潤を伴う下顎歯肉癌の2例 Remarkable regression of lower alveolus and gingival carcinoma by chemotherapy with TS-1 : Report of two cases
We describe two cases of lower gingival carcinoma deeply invading the mandible that remarkably regressed in response to TS-1 chemotherapy. Patient 1, a 73-year-old woman, presented with hypoesthesia of the right lower lip. Clinical examination revealed an ulcerated lesion with induration in the right lower side of the gingiva. Orthopantomography showed a tumor deeply invading the mandible. Biopsy revealed a well-differentiated squamous cell carcinoma. Electrocardiography showed ischemic heart disease, requiring immediate treatment. She underwent percutaneous transluminal coronary angioplasty (PTCA) before mandiblectomy. Twelve days before the operation, she was given TS-1, because the bone defect worsened despite treatment with UFT during cardiovascular therapy. Patient 2, a 61-year-old woman, presented with an ulcerative lesion in the right lower side of the gingiva. Orthopantomography showed an extensive bone defect in the right side of the mandible. After histopathological diagnosis confirmed squamous cell carcinoma, chemotherapy with TS-1 was started 8 days before the operation. Histopathological findings showed that the tumors in both patients regressed remarkably in response to TS-1.
日本口腔外科学会雑誌 50(10), 608-611, 2004-10-20
Japanese Society of Oral and Maxillofacial Surgeons