Correlation of the expression of telomerase subunits with telomerase activity in oral squamous cell carcinoma

• HIDAKA Keitaro

  Department of Oral & Maxillofacial Surgery, Fukuoka Dental College

Bibliographic Information

Other Title

• 口腔へん平上皮癌におけるテロメラーゼ活性とテロメラーゼ構成要素との関連性

Abstract

Telomerase activity is thought to be crucial for the sustained growth or progression of most cancer cells, and its activation is an important step in carcinogenesis. Recently, three major subunits of human telomerase, h TR, h TEP1 and h TERT, have been identified. In this study, we quantified the m RNA expression of these telomerase subunits in oral tissues by RT PCR and evaluated the correlation between expression and telomerase activity. Telomerase activity was detected in oralleukoplakia (75%) and oral squamous cell carcinoma (SCC)(66.7%). Expression of both h TEP1 and h TR was detected in all tissue samples tested, including normal gingiva. In contrast, h TERT expression was detected in 12 of 22 (54.5%) oral leukoplakia and SCC samples and was negative in normal gingiva samples. In addition, expression of h TERT well correlated with telomerase activity. Detection of h TERTexpression in oral lesions might be a diagnostic biomarker of leukoplakia or oral cancer.

Journal

• Japanese Journal of Oral and Maxillofacial Surgery

  Japanese Journal of Oral and Maxillofacial Surgery 50 (8), 466-470, 2004

  Japanese Society of Oral and Maxillofacial Surgeons

Keywords

• oral squamous cell carcinoma
• telomerase
• human telomerase reverse transcriptase
• human telomerase RNA
• human telomerase-associated protein

Details

• CRID: 1390282681509683328
• NII Article ID: 10018619379
• NII Book ID: AN00189163
• DOI: 10.5794/jjoms.50.466
• ISSN: 21861579
• ISSN: 00215163
• Web Site: https://search.jamas.or.jp/link/ui/2005017007
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed