頬部腫瘤を主訴としCHOP療法とモノクロナール抗体療法を併用した悪性リンパ腫の1例 Combination chemotherapy with CHOP and monoclonal antibody for malignant lymphoma with a tumor of the cheek as the chief complaint : A case report

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著者

    • 矢郷 香 YAGO Kaori
    • 慶應義塾大学医学部歯科口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University
    • 金納 利絵 KINNO Rie
    • 慶應義塾大学医学部歯科口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University
    • 中川 種昭 NAKAGAWA Taneaki
    • 慶應義塾大学医学部歯科口腔外科学教室 Department of Dentistry and Oral Surgery, School of Medicine, Keio University

抄録

Rituximab is a chimeric monoclonal antibody directed against the B-cell CD20 antigen, which has been used for the therapy of B-cell non-Hodgkin lymphoma. It was approved by the Japanese Ministry of Health, Labour and Welfare in June 2001.<BR>We report a case of malignant lymphoma in the oral and maxillofacial region that was treated with rituximab and a combination of cyclophosphamide, doxorubicine, vincristin, and prednisolone (CHOP) and had an excellent response.<BR>The patient was a 62-year-old woman who had a swelling on the right side of the cheek. A computed tomographic scan revealed a mass measuring 33×30mm in the cheek with several swollen cervical lymph nodes. Biopsy of the cheek revealed lymphoid proliferation, consistent with malignant non-Hodgkin lymphoma (diffuse large Bcell lymphoma). Immunohistochemical staining was positive for CD20. The patient was therefore treated with rituximab and CHOP, and the tumor disappeared. One year 3 months have passed since treatment, and there is no evidence of recurrence.<BR>This is the first reported case of an excellent response of a malignant lymphoma in the oral and maxillofacial region to rituximab and CHOP in Japan.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 50(4), 247-250, 2004-04-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018620220
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00215163
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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