Perforation of the small intestine developed in two patients with chronic renal failure receiving nonsteroidal anti-inflammatory drugs
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- Sakai Kanaki
- Division of Nephrology, Osaka Rosai Hospital
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- Uzu Takashi
- Division of Nephrology, Osaka Rosai Hospital
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- Chikamori Yasuhiro
- Department of Medicine, Tondabayashi Hospital
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- Nanba Tomoko
- Division of Nephrology, Osaka Rosai Hospital
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- Harada Tamaki
- Division of Nephrology, Osaka Rosai Hospital
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- Takeji Masanobu
- Division of Nephrology, Osaka Rosai Hospital
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- Takahara Ken
- Division of Nephrology, Osaka Rosai Hospital
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- Yamauchi Atsushi
- Division of Nephrology, Osaka Rosai Hospital
Bibliographic Information
- Other Title
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- 非ステロイド性抗炎症薬を使用中に小腸穿孔を発症した腎不全患者の2例
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Abstract
Case 1: A 68-year-old man with chronic renal failure and arteriosclersis obliterans was referred to the department of internal medicine because of abdominal cramps, nausea and vomiting. He had been treated with sulindac for left knee joint pain. Laboratory findings revealed severe metabolic acidosis and the elevated levels of serum creatinine and potassium. Hemodialysis was performed immediately although his symptoms worsened. Since computed tomography of the abdomen showed intra-abdominal free air, he was diagnosed as having gastrointestinal perforation. The patient underwent laparotomy, and the ileum was partially resected. An ulcer on the perforated lesion of the ileum was found.<br>Case 2: A 72-year-old man, with a previous history of myocardial infarction and arteriosclerosis obliterans, was admitted to our hospital because of ileus. He had been on maintenance hemodialysis and was treated with loxoprofen for leg pain. Blood cell count showed leukocytosis, and blood chemistry showed an elevated level of CRP. As computed tomography showed abdominal free air and ascites, perforation of the gastrointestinal tract was diagnosed. The patient underwent laparotomy, and perforation of the jejunum was found.<br>Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal perforation is relatively rare complication. However, recent studies have confirmed that the small intestine is a common site for adverse effects of NSAIDs. Therefore, intestinal injury and ulceration induced by NSAIDs should be considered in patients with chronic renal failure who complain of chronic pain and are being treated with NSAIDs.
Journal
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- Nihon Toseki Igakkai Zasshi
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Nihon Toseki Igakkai Zasshi 38 (12), 1793-1797, 2005
The Japanese Society for Dialysis Therapy
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Keywords
Details 詳細情報について
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- CRID
- 1390001204677049856
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- NII Article ID
- 130003721879
- 10018623133
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- NII Book ID
- AN10432053
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- ISSN
- 1883082X
- 13403451
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed