Variable Unstressed Volume Keeps Normal Distributions of Canine Left Ventricular Contractility and Total Mechanical Energy under Atrial Fibrillation

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著者

    • Mohri Satoshi MOHRI Satoshi
    • Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Ito Haruo [他] ITO Haruo
    • Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • YAMAGUCHI Hiroki
    • Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • SANO Shunji
    • Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • SUGA Hiroyuki
    • Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

We have reported that the contractility index (<i>E</i><sub>max</sub>) and the total mechanical energy (PVA) of arrhythmic beats of the left ventricle (LV) distribute normally in canine hearts under electrically induced atrial fibrillation (AF). Here, <i>E</i><sub>max</sub> is the ventricular elastance as the slope of the end-systolic (ES) pressure-volume (P-V) relation (ESPVR), and PVA is the systolic P-V area as the sum of the external mechanical work within the P-V loop and the elastic potential energy under the ESPVR. To obtain <i>E</i><sub>max</sub> and PVA, we had to assume the systolic unstressed volume (<i>V</i><sub>o</sub>) as the V-axis intercept of the ESPVR to be constant despite the varying <i>E</i><sub>max</sub>, since there was no method to obtain <i>V</i><sub>o</sub> directly in each arrhythmic beat. However, we know that in regular stable beats <i>V</i><sub>o</sub> decreases by ∼7 ml/100 g LV with ∼100 times the increases in <i>E</i><sub>max</sub> from ∼0.2 mmHg/(ml/100 g LV) of almost arresting weak beats to ∼20 mmHg/(ml/100 g LV) of strong beats with a highly enhanced contractility. In the present study, we investigated whether <i>E</i><sub>max</sub> and PVA under AF could still distribute normally, despite such <i>E</i><sub>max</sub>-dependent <i>V</i><sub>o</sub> changes. The present analyses showed that the <i>E</i><sub>max</sub> changes were only ∼3 times at most from the weakest to the strongest arrhythmic beat under AF. These changes were not large enough to affect <i>V</i><sub>o</sub> enough to distort the frequency distributions of <i>E</i><sub>max</sub> and PVA from normality. We conclude that one could practically ignore the slight <i>E</i><sub>max</sub> and PVA changes with the Emax-dependent <i>V</i><sub>o</sub> changes under AF.<br>

収録刊行物

  • The Japanese journal of physiology  

    The Japanese journal of physiology 55(5), 255-264, 2005-10-01 

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  25件

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各種コード

  • NII論文ID(NAID)
    10018623883
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    7836830
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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