Microarray-based Identification of Novel Biomarkers in Asthma

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  • Izuhara Kenji
    Division of Medical Biochemistry, Department of Biomolecular Sciences, National Research Institute for Child Health & Development Division of Medical Research, Center for Comprehensive Community Medicine, Saga Medical School, National Research Institute for Child Health & Development
  • Saito Hirohisa
    Department of Allergy and Immunology, National Research Institute for Child Health & Development

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Bronchial asthma is a complicated and diverse disorder affected by genetic and environmental factors. It is widely accepted that it is a Th2-type inflammation originating in lung and caused by inhalation of ubiquitous allergens. The complicated and diverse pathogenesis of this disease yet to be clarified. Functional genomics is the analysis of whole gene expression profiling under given condition, and microarray technology is now the most powerful tool for functional genomics. Several attempts to clarify the pathogenesis of bronchial asthma have been carried out using microarray technology, providing us some novel biomarkers for diagnosis, therapeutic targets or understanding pathogenic mechanisms of bronchial asthma. In this article, we review the outcomes of these analyses by the microarray approach as applied to this disease by focusing on the identification of novel biomarkers.<br>

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