Effects of Salmeterol Xinafoate and Fluticasone Propionate on Immunological Activation of Human Cultured Mast Cells
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- Akabane Hirotomo
- Department of Pharmacology, Gifu Pharmaceutical University
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- Murata Masayuki
- Department of Pharmacology, Gifu Pharmaceutical University
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- Kubota Masafumi
- Department of Clinical Pharmacy, Gifu Pharmaceutical University
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- Takashima Eiji
- Department of Clinical Pharmacy, Gifu Pharmaceutical University
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- Tanaka Hiroyuki
- Department of Pharmacology, Gifu Pharmaceutical University
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- Inagaki Naoki
- Department of Pharmacology, Gifu Pharmaceutical University
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- Horiba Michiaki
- Department of Respiratory Medicine, Ogaki Municipal Hospital
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- Nagai Hiroichi
- Department of Pharmacology, Gifu Pharmaceutical University
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Background: The clinical efficacy of combination therapy comprising a long acting β2-agonist (LABA) and corticosteroid is widely recognized for the treatment of adult asthma. Here we examine the effect of salmeterol xinafoate (SX) and fluticasone propionate (FP) alone and in combination on the immunological activation of human cultured mast cells (HCMC)in vitro.<br> Methods: HCMC were passively sensitized with IgE antibody and then activated by challenging with anti-IgE antibody. The effect of drugs on the activation of mast cells was examined by measuring the amount of released chemical mediators (histamine, leukotrienes (LT) and prostaglandin D2 (PGD2)) and granulocyte macrophage colony stimulating factor (GM-CSF).<br> Results: The release of each chemical mediator was inhibited by 10-9—10-8M SX but not by 10-10—10-7M FP. The production of GM-CSF was inhibited by a concentration of 10-8M in both drugs and the inhibition was augmented by combined treatment with 10-11M of each drug.<br> Conclusions: The immunological release of chemical mediators (histamine, LT, PGD2) from HCMC was inhibited by SX but not by FP. SX and FP inhibited the production of GM-CSF by HCMC and both drug showed synergistic inhibition in the production of GM-CSF.<br>
収録刊行物
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- Allergology International
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Allergology International 55 (4), 387-393, 2006
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390282679611273984
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- NII論文ID
- 130004476912
- 10018643123
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- PubMed
- 17130681
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
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- 使用不可