Effective Synthesis of 5-Substituted Butenolide Derivatives by Using Cinchonidine-derived Quaternary Ammonium Phenoxide Catalyst
A vinylogous aldol-type reaction between 4-methyl-2-(trimethylsiloxy)furan and aldehydes catalyzed by cinchonidine-derived quaternary ammonium phenoxide proceeded smoothly to afford the corresponding 5-substituted butenolide derivatives in high yields with good to excellent diastereo- and enantio-selectivities.
- Chemistry letters
Chemistry letters 36(1), 8-9, 2007-01-05
The Chemical Society of Japan