Chloroform Is Not Solvent but Activator for Cobalt Complex Catalyst of Enantioselective Borohydride Reduction
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For the enantioselective borohydride reduction of carbonyl compounds catalyzed by the optically active ketoiminatocobalt complexes, chloroform has been employed as a unique solvent for achieving a high enantioselectivity, whereas it was found that a catalytic amount of chloroform effectively activated the present catalytic system to convert various ketones into the corresponding reduced product with a high ee in the THF solvent.
- Chemistry Letters
Chemistry Letters 36(1), 26-27, 2007-01-05
The Chemical Society of Japan