Asymmetric Autocatalysis Induced by Octahedral Tris(acetylacetonato)chromium(III) Complex as a Homogeneous Chiral Initiator
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Enantioselective addition of diisopropylzinc to 2-<I>t</I>-butylethynylpyrimidine-5-carbaldehyde in the presence of chiral Δ- and Λ-tris(acetylacetonato)chromium(III) complex [Cr(acac)<SUB>3</SUB>] affords highly enantiomerically enriched (<I>S</I>)- and (<I>R</I>)-5-pyrimidyl alkanols, respectively, in conjunction with asymmetric autocatalysis. The absolute configuration of the corresponding 2-<I>t</I>-butylethynyl-5-pyrimidyl alkanol is dependent upon the chirality of the octahedral chromium(III) complex.
- Chemistry Letters
Chemistry Letters 36(1), 30-31, 2007-01-05
The Chemical Society of Japan