Studies toward Stable Analogues of Guanofosfocins. Synthesis of the Protected Derivative of 8-(5a-Carba-α-D-mannopyranosyloxy)purine Nucleoside
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As a preliminary study directed towards the synthesis of a stable analogue of the guanofosfocins, a methylene analogue of the endocyclic oxygen atom in the mannose moiety, was designed. The construction of the pseudo-α-mannosyl linkage at the 8-position of the purine nucleoside was accomplished by the regioselective ring-opening substitution of the 1,2-<I>O</I>-cyclic sulfate derivative of 5a-carba-mannopyranose.
- Chemistry Letters
Chemistry Letters 36(1), 36-37, 2007-01-05
The Chemical Society of Japan