An Expeditious Synthesis of Lasofoxifene and Nafoxidine via the Novel Three-component Coupling Reaction

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著者

    • SANO Yoshiyuki
    • Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
    • NAKATA Kenya
    • Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
    • OTOYAMA Takafumi
    • Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
    • UMEDA Sei
    • Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
    • SHIINA Isamu
    • Department of Applied Chemistry, Faculty of Science, Tokyo University of Science

抄録

The simple and efficient synthesis of lasofoxifene (<B>4</B>), a possible candidate for alleviating osteoporosis, via the novel three-component coupling reaction among 4-pivaloyloxybenzaldehyde (<B>5</B>), cinnamyltrimethylsilane (<B>6</B>), and anisole in the presence of HfCl<SUB>4</SUB> is illustrated. The successive cationic cyclization of the coupling product, olefin formation, and migration of the double-bond are performed to afford the common synthetic intermediate of lasofoxifene (<B>4</B>) and nafoxidine (<B>3</B>) via a very concise procedure.

収録刊行物

  • Chemistry letters  

    Chemistry letters 36(1), 40-41, 2007-01-05 

    The Chemical Society of Japan

参考文献:  14件

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各種コード

  • NII論文ID(NAID)
    10018662659
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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