An Expeditious Synthesis of Lasofoxifene and Nafoxidine via the Novel Three-component Coupling Reaction

DOI PDF 1 Citations 25 References
  • Yoshiyuki Sano
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
  • Kenya Nakata
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
  • Takafumi Otoyama
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
  • Sei Umeda
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
  • Isamu Shiina
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science

Search this article

Abstract

<jats:title>Abstract</jats:title> <jats:p>The simple and efficient synthesis of lasofoxifene (4), a possible candidate for alleviating osteoporosis, via the novel three-component coupling reaction among 4-pivaloyloxybenzaldehyde (5), cinnamyltrimethylsilane (6), and anisole in the presence of HfCl4 is illustrated. The successive cationic cyclization of the coupling product, olefin formation, and migration of the double-bond are performed to afford the common synthetic intermediate of lasofoxifene (4) and nafoxidine (3) via a very concise procedure.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 36 (1), 40-41, 2006-12-02

    Oxford University Press (OUP)

Citations (1)*help

See more

References(25)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top