Reductive Ti-crossed Claisen Condensation between Methyl α-Bromocarboxylates and Acid Chlorides Utilizing a TiCl_4-PPh_3-N-Methylimidazole Reagent
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Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl<SUB>4</SUB>–PPh<SUB>3</SUB>–<I>N</I>-methylimidazole reagent proceeded smoothly to give the α-monosubstituted and thermodynamically unfavorable α,α-disubstituted β-keto methyl esters in good to excellent yields (33 examples; 73–96% yield).
- Chemistry Letters
Chemistry Letters 36(1), 48-49, 2007-01-05
The Chemical Society of Japan