Alkylation of N-Protecting Group-free Indole with Vinyl Ketones Using Iron Salt Catalyst

• Toshiyuki Itoh

  Department of Materials Science, Faculty of Engineering, Tottori University

• Hiroyuki Uehara

  Department of Materials Science, Faculty of Engineering, Tottori University

• Koji Ogiso

  Department of Materials Science, Faculty of Engineering, Tottori University

• Shun Nomura

  Department of Materials Science, Faculty of Engineering, Tottori University

• Shuichi Hayase

  Department of Materials Science, Faculty of Engineering, Tottori University

• Motoi Kawatsura

  Department of Materials Science, Faculty of Engineering, Tottori University

抄録

Indole was reacted with vinyl ketones in the presence of 3 mol % of iron(II) tetrafluoroborate in acetonitrile or ionic liquids to give 3-alkylated product in an excellent yield. 2,3-Dialkylated indole was also obtained when the reaction was carried out using an excess amount of methyl vinyl ketone with the same catalyst; the results were significantly dependent on the reaction medium and both methanol and ionic liquid were found to be good solvents for double alkylation of indole.

収録刊行物

• Chemistry Letters

  Chemistry Letters 36 (1), 50-51, 2006-12-16

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360283694087718016
• NII論文ID: 10018662750
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.2007.50
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/36/1/50/55593848/cl.2007.50.pdf
• データソース種別:
  • Crossref
  • CiNii Articles