Iron-catalyzed Direct-type Hydroxymethylation of 1,3-Dicarbonyl Compounds in Water

  • Chikako Ogawa
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency (JST)
  • Shu Kobayashi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency (JST)

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<jats:title>Abstract</jats:title> <jats:p>Direct-type hydroxymethylation of 1,3-dicarbonyl compounds with aqueous formaldehyde proceeded smoothly in water in the presence of Fe(NO3)3·9H2O and sodium dodecylbenzenesulfate (SDBS), to afford the corresponding products in good to high yields.</jats:p>

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  • Chemistry Letters

    Chemistry Letters 36 (1), 56-57, 2006-12-16

    Oxford University Press (OUP)

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