Mechanisms of Cadmium Transport in Mammalian Cells (特集1:若手が拓く微量元素研究の最前線) Mechanisms of Cadmium Transport in Mammalian Cells

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According to early studies on the transport of cadmium (Cd), it was suggested that iron (Fe) or calcium (Ca) transport system is important in Cd incorporation into cells based on the evidence that dietary Fe or Ca deficiency enhanced intestinal Cd absorption. Transporter of Fe, divalent metal transporter, was shown to be capable of permeating other divalent metals including Cd. On the other hand, L-type Ca channel was also shown to be responsible at least in part, for cellular Cd uptake. In addition to Ca and Fe, it was suggested that the transporter for cellular incorporation of manganese (Mn) and zinc (Zn) may also be involved in Cd uptake by using Cd-resistant metallothionein null cells. Recently, two members of ZIP family, ZIP8 (Slc39a8) and ZIP14 (Slc39a14) have been suggested as the candidates for Cd transporter. ZIP8 was found to be the determinant for the sensitivity to Cd-induced testicular hemorrhage. ZIP14 was down-regulated in Cd-resistant metallothionein null cells. Further characterization of the roles of ZIP8 and ZIP14 in the transport of Cd, Mn and Zn is needed to clarify Cd transport system in mammals.

収録刊行物

  • Biomedical research on trace elements  

    Biomedical research on trace elements 17(4), 349-354, 2006-12-31 

    Japan Society for Biomedical Research on Trace Elements

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各種コード

  • NII論文ID(NAID)
    10018664281
  • NII書誌ID(NCID)
    AN10423256
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0916717X
  • NDL 記事登録ID
    8664422
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-3255
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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