Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp. (特集1:若手が拓く微量元素研究の最前線) Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp.

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We investigated the <I>in vitro</I> and <I>in vivo</I> effects of metal ions on the activity of an alpha-glucosidase (<I>Saccharomyces sp</I>.). CuSO<SUB>4</SUB>, ZnSO<SUB>4</SUB>, and VOSO<SUB>4</SUB> significantly inhibited the alpha-glucosidase activity <I>in vitro</I>. Additionally, we examined their effects on the blood glucose level by performing oral carbohydrate tolerance tests in both normal ddY mice and streptozotocin-induced diabetic mice. After oral administration of these three metal compounds, the elevation in the blood glucose levels in mice administered disaccharide (sucrose) was significantly suppressed in comparison with untreated mice. On the other hand, the elevation in the blood glucose levels in mice administered monosaccharide (glucose) was not suppressed when such compounds or a vehicle was administered. The results suggested that some metal ions suppress disacharide digestion probably due to the inhibition of the alpha-glucosidase activity in the epithelium of the small intestine.

収録刊行物

  • Biomedical research on trace elements  

    Biomedical research on trace elements 17(4), 360-364, 2006-12-31 

    Japan Society for Biomedical Research on Trace Elements

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各種コード

  • NII論文ID(NAID)
    10018664351
  • NII書誌ID(NCID)
    AN10423256
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0916717X
  • NDL 記事登録ID
    8664725
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-3255
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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