Inhibitory Modulation of Glutamatergic Neuron Activity by Zinc in the Hippocampus

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Zinc exists in high densities in the giant boutons of hippocampal mossy fibers. Zinc decreases extracellular glutamate concentration in the hippocampus, suggesting inhibitory modulation of glutamatergic neurotransmitter system by zinc. Zinc-specific fluorescent (ZnAF-2) signals are increased in both extracellular and intracellular compartments in the mossy fiber terminals during the delivery of tetanic stimuli to the dentate granule cell layer. It is likely that zinc released from mossy fibers is immediately retaken up by mossy fibers and taken up into postsynaptic CA3 neurons. In mossy fiber terminals preferentially double-stained with zinc and calcium indicators, the increase in calcium orange signal during delivery of tetanic stimuli to the dentate granule cell layer is enhanced by addition of CaEDTA, a membrane-impermeable zinc chelator, while suppressed by addition of zinc. The decrease in FM4-64 signal (vesicular exocytosis) during tetanic stimulation, which induces mossy fiber long-term potentiation, is also enhanced in mossy fiber terminals by addition of CaEDTA and is suppressed by addition of zinc. Zinc released from mossy fibers may serve as a negative-feedback factor of presynaptic activity.

収録刊行物

  • Biomedical research on trace elements  

    Biomedical research on trace elements 17(4), 399-405, 2006-12-31 

    Japan Society for Biomedical Research on Trace Elements

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各種コード

  • NII論文ID(NAID)
    10018664513
  • NII書誌ID(NCID)
    AN10423256
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0916717X
  • NDL 記事登録ID
    8664883
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-3255
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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