Time course of cerebral blood flow changes following electroconvulsive therapy in depressive patients—measured at 3 time points using single photon emission computed tomography

• Takano Harumasa

  Department of Neuropsychiatry, School of Medicine, Keio University

• Kato Motoichiro

  Department of Neuropsychiatry, School of Medicine, Keio University

• Inagaki Ataru

  Department of Neuropsychiatry, School of Medicine, Keio University

• Watanabe Koichiro

  Department of Neuropsychiatry, School of Medicine, Keio University

• Kashima Haruo

  Department of Neuropsychiatry, School of Medicine, Keio University

書誌事項

タイトル別名

• Time course of cerebral blood flow changes following electroconvulsive therapy in depressive patients-measured at 3 time points using single photon emission computed tomography

抄録

Although electroconvulsive therapy (ECT) has been employed for treating depression for more than 60 years, its mechanisms of action are yet unknown. To clarify the ECT effects on brain function, we examined cerebral blood flow (CBF) using single photon emission computed tomography at 3 time points-few days before an ECT course (Pre) and approximately 5 days (Post 1) and 1 month (Post 2) after the last ECT session. Eight depressive patients completed the study. In all the patients, the depressive symptoms improved after the ECT course, and major cognitive impairment was not observed at any time point. At Pre, the regional CBF (rCBF) in the widespread areas in the frontal lobe and limbic regions including cingulate cortex and parahippocampal gyrus was lower in the patients than in the normal controls. At Post 1 and Post 2, the rCBF in the frontal and limbic regions continued to be lower in the patients than in the controls although the successive recovery of decreased rCBF in the frontal region was observed. Regarding the time course among the patients, the rCBF in the right medial frontal region significantly increased (toward normal) at Post 2, not at Post 1. These findings suggest that depressive patients have decreased CBF in the frontal and limbic regions, and the medial frontal region plays a crucial role in ECT and recovery from depression. Further, patients who have undergone ECT treatment for depression should be carefully observed because brain functions continue to change even after a successful ECT course.

収録刊行物

• Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ

  Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ 55 (4), 153-160, 2006

  The Keio Journal of Medicine

キーワード

• depression
• electroconvulsive therapy (ECT)
• single photon emission computed tomography (SPECT)
• brain mapping

詳細情報

• CRID: 1390001206337343872
• NII論文ID: 10018671283
• NII書誌ID: AA00710216
• DOI: 10.2302/kjm.55.153
• COI: 1:STN:280:DC%2BD28jltlCrtQ%3D%3D
• ISSN: 18801293
• ISSN: 00229717
• PubMed: 17191070
• Web Site: https://www.jstage.jst.go.jp/article/kjm/55/4/55_4_153/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007175168
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可