Effect of calcium carbonate administration on metabolic acidosis induced by sevelamer hydrochloride in chronic hemodialysis patients

• Matsushita Yoshio

  Department of Nephrology, Kumamoto Chuo Hospital

• Yamauchi Eiji

  Department of Nephrology, Kumamoto Chuo Hospital

• Matsuoka Kiyoshi

  Department of Nephrology, Kumamoto Chuo Hospital

• Arizono Kenji

  Department of Nephrology, Kumamoto Chuo Hospital

Bibliographic Information

Other Title

• 塩酸セベラマー投与による代謝性アシドーシスにおける沈降炭酸カルシウム投与の効果に関する検討
• エンサン セベラマー トウヨ ニ ヨル タイシャセイ アシドーシス ニ オケル チンコウ タンサン カルシウム トウヨ ノ コウカ ニ カンスル ケントウ

Abstract

It has been reported that serum bicarbonate levels decrease in chronic hemodialysis patients treated with sevelamer hydrochloride, whereas these levels increase with calcium-containing phosphate binders. We investigated the effect of calcium carbonate administration on serum bicarbonate levels and metabolic acidosis in chronic hemodialysis patients treated with sevelamer hydrochloride.<br>Sixteen chronic hemodialysis patients were studied (M/F; 8/8, age; 51.0±9.6y, hemodialysis duration; 58.0±56.0m). All subjects were treated with sevelamer hydrochloride at 2.25g/day for 2 weeks, then increased to 2.95±1.4g/day for 2 weeks. After discontinuing sevelamer hydrochloride followed by wash out for 8 weeks, they were again treated with sevelamer hydrochloride at 2.25g/day for 2 weeks, then increased to 2.95±1.4g/day for 2 weeks with calcium carbonate at 1.5g/day. Serum bicarbonate levels were measured before hemodialysis.<br>Serum bicarbonate levels with sevelamer hydrochloride significantly decreased from 23.2±1.86 to 20.3±1.40 after 2 weeks (p<0.0001) and 19.9±2.07mmol/L after 4 weeks (p<0.000001). Serum bicarbonate levels with sevelamer hydrochloride and calcium carbonate also significantly decreased from 23.0±1.68 to 21.5±2.23 after 2 weeks (p<0.05) and 20.9±2.37mmol/L after 4 weeks (p<0.01) respectively. Metabolic acidosis induced by sevelamer hydrochloride was significantly mitigated by calcium carbonate (after 4 weeks with sevelamer hydrochloride vs after 4 weeks with sevelamer hydrochloride and calcium carbonate; p<0.01).<br>Administering calcium carbonate improves metabolic acidosis induced by sevelamer hydrochloride in hemodialysis patients.

Journal

• Nihon Toseki Igakkai Zasshi

  Nihon Toseki Igakkai Zasshi 39 (7), 1245-1250, 2006

  The Japanese Society for Dialysis Therapy

Keywords

• 塩酸セベラマー
• 沈降炭酸カルシウム
• 代謝性アシドーシス
• 血液透析

Details

• CRID: 1390282679653531520
• NII Article ID: 130003721970
• NII Article ID: 10018674943
• NII Book ID: AN10432053
• DOI: 10.4009/jsdt.39.1245
• ISSN: 1883082X
• ISSN: 13403451
• NDL BIB ID: 8050347
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8050347
• Web Site: https://search.jamas.or.jp/link/ui/2006317472
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed