Combination Chemotherapy (CVP) in a Patient with Refractory Idiopathic Thrombocytopenic Purpura (ITP)

• INOUE Yasuyuki

  Japanese Red Cross Medical Center, Department of Hematology

• NAKAGAWA Yasunori

  Japanese Red Cross Medical Center, Department of Hematology

• SAWANOBORI Masakazu

  Japanese Red Cross Medical Center, Department of Hematology

• SUZUKI Kenshi

  Japanese Red Cross Medical Center, Department of Hematology

• ENOMOTO Hidetoshi

  Japanese Red Cross Medical Center, Department of Hematology

Bibliographic Information

Other Title

• 併用化学療法（CVP療法）に反応が認められたステロイドおよび摘脾抵抗性ITP

Abstract

A 54-year-old woman, who had been given a diagnosis of idiopathic thrombocytopenic purpura (ITP) refractory to steroid therapy, was admitted to our hospital because of severe bleeding tendency. Splenectomy, high dose vitamin-C and interferon-α were not effective, although high-dose γ-globulin had some effect. Since high-dose glucocorticoid was effective temporarily, we decided to perform chemotherapy. Seven courses of CVP chemotherapies (CVP; CPM 500 mg, VCR 2 mg, PSL 50 mg) prevented severe bleeding and did not have serious toxicity. Chemotherapy can be indicated for refractory ITP reactive to immunosuppressive therapy such as high-dose glucocorticoid.

Journal

• Rinsho Ketsueki

  Rinsho Ketsueki 39 (3), 193-197, 1998

  The Japanese Society of Hematology

Keywords

• refractory ITP
• CVP chemotherapy

Details

• CRID: 1390282680009508864
• NII Article ID: 10018675047
• NII Article ID: 130004500441
• NII Article ID: 10005900238
• NII Book ID: AN00252940
• DOI: 10.11406/rinketsu.39.193
• COI: 1:STN:280:DyaK1c3jvVGjsQ%3D%3D
• ISSN: 18820824
• ISSN: 04851439
• PubMed: 9577642
• Web Site: https://search.jamas.or.jp/link/ui/1998187355
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed