A case of xanthogranulomatous changes of the liver with marked increase in serological tumor markers and misdiagnosed for recurrence of hepatocellular carcinoma

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Other Title
  • 腫瘍マーカーの急上昇を伴い肝細胞癌再発と誤診した黄色肉芽腫性腫瘤の１例
  • 症例報告 腫瘍マーカーの急上昇を伴い肝細胞癌再発と誤診した黄色肉芽腫性腫瘤の1例
  • ショウレイ ホウコク シュヨウ マーカー ノ キュウジョウショウ オ トモナイ カン サイボウガン サイハツ ト ゴシン シタ オウショク ニクゲシュセイ シュリュウ ノ 1レイ
  • 肝細胞癌の年代別発生傾向
  • カン サイボウ ガン ノ ネンダイベツ ハッセイ ケイコウ
  • Chronological analysis for the hepatocellular carcinoma development

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Abstract

Serum tumor makers for hepatocellular carcinoma (HCC), α-fetoprotein (AFP) and its fraction of lens culimaris agglutinin A-reactive alpha-protein (AFP L3), protein induced by vitamin K absence or antagonist-prothrombin (Factor II) (PIVKA-II), are widely used in clinical stage. They sometimes increase with non-cancerous condition, but it is extremely rare that they increase simultaneously in abundance. We reported a case of HCC, a 67-year-old man who experienced hepatectomy two times for HCC, with marked increase of tumor markers, AFP, L3 and PIVKA-II, and showed a mass lesion in preoperative examination. We misdiagnosed this case for recurrence of HCC and S4 liver resection was performed. Postoperative pathological examination revealed a xanthogranulomatous change but no HCC cells. The patient died about 11months after his third hepatectomy for postoperative complication of biliobronchial fistula. An autopsy showed no tumor recurrence in local or distant area.<br>

Journal

  • Kanzo

    Kanzo 47 (12), 558-565, 2006

    The Japan Society of Hepatology

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