固定化リポソームセンサーと膜関連疾病への応用 Immobilized Liposome Sensor and Its Application to Membrane-Related Diseases

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著者

    • 久保井 亮一 KUBOI Ryoichi
    • 大阪大学 大学院基礎工学研究科 物質創成専攻 Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University
    • 馬越 大 UMAKOSHI Hiroshi
    • 大阪大学 大学院基礎工学研究科 物質創成専攻 Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University
    • 島内 寿徳 SHIMANOUCHI Toshinori
    • 大阪大学 大学院基礎工学研究科 物質創成専攻 Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University

抄録

The diseases caused by the membrane disorder or damages are categorized as the Membrane-related diseases. Alzheimer's disease (AD), which is one of the membrane-related diseases, has been considered to be accompanied by the oxidative damage of the neuronal cell membrane. Amyloid β-peptide (Aβ), which is a pathological key peptide of AD, interacts with biomembrane and this interaction has been recently paid attention from the viewpoints of not only conformational abnormality but also the influence to biomembrane. And therefore, the modeling of biomembrane using liposome has been desired to develop the liposome-based sensor system. In this article, we surveyed the sensor system using liposome. Firstly, the immobilization techniques for preparation of the immobilized-liposome sensor are surveyed. Secondary, some kinds of sensor have been introduced: (i) (metal affinity) immobilized-liposome chromatography, (ii) immobilized-liposome quartz crystal microbalance method, (iii) immobilized-liposome sensor (Amperometric method), (iv) membrane chip system. These techniques have been developed in a framework of "Membrane Stress Biotechnology". The above methodologies could provide us the quantitative properties of stress responsive function of both the protein and the membrane.

収録刊行物

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    膜 32(1), 32-39, 2007-01-01 

    THE MEMBRANE SOCIETY OF JAPAN

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各種コード

  • NII論文ID(NAID)
    10018696288
  • NII書誌ID(NCID)
    AN0023215X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03851036
  • NDL 記事登録ID
    8662475
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z18-1127
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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