Clinical efficacy of high dose treatment with teicoplanin (TEIC) against MRSA infections and trough concentration of TEIC

DOI 6 Citations 26 References
  • Ueda Yasuharu
    Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital
  • Noguchi Shusaku
    Department of Pharmacy, Nippon Medical School Musashikosugi Hospital
  • Makin Masahiko
    Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital
  • Kamisasa Hiroshi
    Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital
  • Mochizuki Toru
    Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital
  • Unemoto Kyoko
    Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital
  • Kurokawa Akira
    Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital

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  • Ｔｅｉｃｏｐｌａｎｉｎ高用量投与の有用性と血中濃度

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Abstract

We analyzed the clinical efficacy of high dose teicoplanin (TEIC)(1, 600 mg/24 h for the first day and 800 mg/24 h thereafter) and plasma trough concentration of TEIC in MRSA infections in Emergency and Critical Care Medicine, to examine the relationship between a change in the trough concentration after administration of this drug and efficacy and safety.<BR>Results are as follows:<BR>1. The clinical efficacy of TEIC against 10 cases of pneumonia, 2 of septicemia with wound infection due toMRSA was 100%.<BR>2. The bacteriological effectiveness of TEIC consisted of 9 eradicated, 1 decreased, 2 replaced, and O unchanged. Among 8 patients treated with TEIC alone, it consisted of 7 eradicated, O decreased, 1 replaced, and O unchanged. Among 4 patients concomitantly treated with other drugs, it consisted of 2 eradicated, 1 decreased, 1 replaced, and O unchanged. Four of 12 patients showed multibacterial infection with Pseudomonas aeruginosa.<BR>3. No case administered TEIC was found to have any side effects or abnormal laboratory findings. 4. The trough blood TEIC level slightly decreased to 17.5 ±6.7 μg/mL on day 2 and 16.3 ±6.3μg/mL on day 4, showing a steady state, and accumulation of TEIC was as mild as 20.5 ±6.9μg/mL on day 8. There<BR>5. High-dose treatment with TEIC showed highly sharp efficacy and high safety, which was considered to be a very useful method for treatment of severe MRSA infections. was no variation of blood concentrations in the respective patients, moreover.

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