Population pharmacokinetics of teicoplanin in infants and children

• Kobayashi Masahiro

  Department of Pharmacy, Kitasato University Hospital

• Arima Misayo

  Department of Pharmacy, Kitasato University Hospital

• Kimura Toshimi

  Department of Pharmacy, Kitasato University Hospital

• Ishii Masahiro

  Department of Pediatrics, School of Medicine, Kitasato University

• Yago Kazuo

  Department of Pharmacy, Kitasato University Hospital

• Sunakawa Keisuke

  Department of Infectious Disease, School of Medicine, Kitasato University

Bibliographic Information

Other Title

• 小児におけるｔｅｉｃｏｐｌａｎｉｎの母集団薬物動態解析

Abstract

We analyzed teicoplanin (TEIC) pharmacokinetics in infants and children using the nonlinear mixed effects model (NONMEM) to estimate population pharmacokinetics parameters. Subjects were 63 children (28 days to 16 years old) prescribed TEIC at Kitasato University Hospital and undergoing therapeutic drug monitoring. Population pharmacokinetics parameters were calculated using 1-compartment model of clearance (CL_TEIC) and volume of distribution (Vd_TEIC). An exponential error model was used to determine interindividual variability and a relative error model for residual variability. Patient age, gender, weight, serum creatinine, and serum albumin were covariates. The observed TEIC serum concentration was 101 points ranging from 4.4-39.1ug/mL. TEIC population pharmacokinetics parameters finally estimated were: CL_TEIC=0.00836×(wt/Scr) ⁰⁷⁸⁶ (L/h) and Vd_TEIC=0.8× wt (L). Interindividual variability was CL_TEIC=26.7 (%) and Vd_TEIC=32.7 (%), and residual variability was 2.8, μg/mL. CL_TEIC changes due to aging correlated well with that of kidney gravity. Model validity was sufficient. Our reports suggest that the population parameters are useful in evaluating TEIC pharmacokinetics in children undergoing long-term hospitalization.

Journal

• Japanese Journal of Chemotherapy

  Japanese Journal of Chemotherapy 55 (1), 17-22, 2007

  Japanese Society of Chemotherapy

Keywords

• teicoplanin
• population pharmacokinetics
• NONMEM
• child

Details

• CRID: 1390282681261309312
• NII Article ID: 130004102760
• NII Article ID: 10018697674
• NII Book ID: AN10472127
• DOI: 10.11250/chemotherapy1995.55.17
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2007144869
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed