Mass Spectrometric Elucidation of Phenolic Oxidation Processes with Cu^<2+>-Adduct

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Formation of ε complex with 2-hydroxy-6-[8′(Z),11′(Z),14′-pentadecatrienyl]benzoic acid (anacardic acid) and copper ion in the respective ratios of 2 : 1 and 1 : 1 at room temperature was observed by electrospray ionization mass spectrometry. The oxidation of 3-(3,4-dihydroxyphenyl)alanine (DOPA) in the presence of anacardic acid showed competitive inhibition with temporary reduction from dopaquinone to DOPA. In the oxidation of neurotensin, the oxidized products, dopaquinone-derivatives, were observed. Mass spectrometry revealed that the enzymatic oxidation of tyrosine residue is inhibited by anacardic acid.

Formation of ε complex with 2-hydroxy-6-[8′(<i>Z</i>),11′(<i>Z</i>),14′-pentadecatrienyl]benzoic acid (anacardic acid) and copper ion in the respective ratios of 2 : 1 and 1 : 1 at room temperature was observed by electrospray ionization mass spectrometry. The oxidation of 3-(3,4-dihydroxyphenyl)alanine (DOPA) in the presence of anacardic acid showed competitive inhibition with temporary reduction from dopaquinone to DOPA. In the oxidation of neurotensin, the oxidized products, dopaquinone-derivatives, were observed. Mass spectrometry revealed that the enzymatic oxidation of tyrosine residue is inhibited by anacardic acid.

収録刊行物

  • 質量分析 = Mass spectroscopy

    質量分析 = Mass spectroscopy 55(1), 7-13, 2007-02-01

    日本質量分析学会

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各種コード

  • NII論文ID(NAID)
    10018702948
  • NII書誌ID(NCID)
    AN0010555X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13408097
  • NDL 記事登録ID
    8675173
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z17-213
  • データ提供元
    CJP書誌  NDL  IR  J-STAGE 
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