Changes of complement in recurrent abortion and pregnancy loss with antiphospholipid antibody positive

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  • SASAKI Shigetane
    Department of Obstetrics and Gynecology, Nihon University School of Medicine
  • MURASE Takayuki
    Department of Obstetrics and Gynecology, Nihon University School of Medicine
  • KUNO Souichirou
    Department of Obstetrics and Gynecology, Nihon University School of Medicine
  • YAMAMOTO Tatsuo
    Department of Obstetrics and Gynecology, Nihon University School of Medicine

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  • 流産または死産をくりかえした抗リン脂質抗体陽性例における補体の変動

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Abstract

  In order to know the comlement activation, the changes of compliment were evaluated in recurrent abortion and pregnancy loss patients with antiphospholipid antibody (APA) positive. Serum samples were taken from 82 patients with more than 2 recurrent abortion patients and/or pregnancy loss. Fifty eight cases of 82 patients were APA and antinuclear antibody negative without autoimmune disease. Anticardiolipin antibody (ACA), anti CL/β2-GPI antibody (CL/β2-GPI) were measured using ELISA. Lupus anticoagulant (LAC) was measured using diluted RVVT. CH50 and C3 and C4 were measured as complements. The number of positive cases of ACA, CL/β2-GPI, LAC was 23, 9 and 5 cases, respectively.<br>   Results: The levels (mean±SD) of CH50, C3 and C4 in ACA positive and negative cases were 38.8±8.3 U/ml, 82.7±20.1 mg/dl, 18.5±5.7 mg/dl and 42.4±6.9 U/ml, 93.5±17.6 mg/dl, 21.1±4.6 mg/dl, respectively. The levels of CH50, C3 and C4 in positive cases were significantly lower than negatives. The levels of CH50, C3 and C4 in CL/β2-GPI and LAC positive cases were also significantly lower than negatives.<br>   Conclusion: The comlement activation was demonstrated in recurrent abortion and pregnancy loss with antiphospholipid antibody positive.<br>

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