A CASE OF ADVANCED RECTOSIGMOIDAL CANCER WITH MARKEDLY ELEVATED PREOPERATIVE CEA LEVEL FOLLOWING A FAVORABLE COURSE

• OBA Masaru

  Department of Surgery, Toyama Rosai Hospital

• MATSUKI Nobuo

  Department of Surgery, Toyama Rosai Hospital

• AJISAKA Hideyuki

  Department of Surgery, Toyama Rosai Hospital

• II Toru

  Department of Surgery, Toyama Rosai Hospital

• MIWA Koichi

  Department of Surgery, Toyama Rosai Hospital

Bibliographic Information

Other Title

• 術前ＣＥＡ値が異常高値をきたした直腸Ｓ状部癌の１切除例

Abstract

We report a case of advanced rectosigmoidal cancer with markedly elevated preoperative carcinoembryonic antigen (CEA) level, who is now 14 months disease-free following the diagnosis after curable resection. A 67-year-old female with hematochezia and constipation was found to have a type 3 tumor in the rectosigmoid by further examination in July 2005. Preoperative serum CEA level was 372. 1 or 402.7 ng/ml without distal involvement or double cancer. She underwent laparoscopically assisted low anterior resection (D3) and her disease was diagnosed as RS, type3, 60×50mm, tub2, SS, ly1, v0, N0, H0, P0, M0. The expression pattern of cytokeratins (CK) 7 and 20 in the adenocarcinoma was CK7^-/CK20⁺. Moreover, mucin peptide core antigens (MUC) and CD 10 expression were respectively MUC1 (-), MUC2 (++), MUC5AC (-) and CD10 (-), which may be relevant to both pathogenesis and prognosis. In some cases of colorectal cancer with markedly elevated preoperative CEA as a poor prognostic factor, a phenotypic approach could provide a survival advantage.

Journal

• Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 68 (1), 146-150, 2007

  Japan Surgical Association

Keywords

• 術前CEA値
• 大腸癌
• 予後因子

Details

• CRID: 1390001204847709696
• NII Article ID: 130004516321
• NII Article ID: 10018716754
• NII Book ID: AA11189709
• DOI: 10.3919/jjsa.68.146
• ISSN: 18825133
• ISSN: 13452843
• Web Site: http://www.jstage.jst.go.jp/article/jjsa/68/1/68_1_146/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007121291
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed