Ochronotic Arthropathy Requiring Bilateral Hip and Knee Joint Arthroplasty: Case Study

DOI 14 References
  • MIYAZAKI Tsuyoshi
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • KOKUBO Yasuo
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • KOBAYASHI Shigeru
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • YAYAMA Takafumi
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • SATO Ryuichiro
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • UCHIDA Kenzo
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • BANGIRANA Alexander
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences
  • BABA Hisatoshi
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences

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Abstract

Ochronosis is a rare disease caused by an inherited lack of homogentisic acid oxidase. It is associated with various systemic abnormalities and related to the deposition of homogentisic acid pigment in connective tissues. This deposition process leads to brittleness, fissuring and fragmentation of the articular cartilage, together with the development of clinically serious ochronotic arthropathy, including spondyloarthropathy. This short communication describes a typical case of an elderly woman with ochronotis who underwent multiple hip and knee arthroplasties over several years, together with a literature review.

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