Age-related NADPH-diaphorase positive bodies in the lumbosacral spinal cord of aged rats

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著者

    • TAN Huibing
    • Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University
    • HE Jianwen
    • Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University
    • WANG Songyan
    • Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University
    • HIRATA Kazuho
    • Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University
    • YANG Zhengwei
    • Morphometric Research Laboratory, North Sichuan Medical College
    • KURAOKA Akio
    • Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University
    • KAWABUCHI Masaru
    • Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University

抄録

In the course of a morphological investigation of age-related changes in the rat spinal cord, using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry, we found abundant NADPH-d positive bodies, which were characteristically expressed in the aged lumbosacral spinal cord. Together with a normally stained fiber network and a few neurons, the dense, spheroidal NADPH-d positive bodies occurred in portions of the sacral dorsal spinal cords, such as the dorsal commissural nucleus, intermediolateral nuclei, and superficial dorsal horn, and were scattered throughout the dorsal white column. These NADPH-d positive bodies were occasionally observed in a fibrous structure. Two morphologically distinctive subsets of NADPH-d positive bodies were noted in the spinal cord of rats aged 8 to 36 months: 1) highly-dense spheroidal shapes with sharp edges; 2) moderately-dense spheroidal or multiangular shapes with a central "core" and a peripheral "halo". The quantitative analysis, particularly the stereological measurement, confirmed a gradual increase in the incidence and size of NADPH-d positive bodies with increasing age. With nNOS immunohistochemistry, no corresponding structures to NADPH-d positive bodies were detected in aged rats; thus NADPH-d activity is not always specific to the NO-containing neural structures. The major distribution of the NADPH-d positive bodies in the aged lumbosacral spinal cord indicates some anomalous changes in the neurite, which might account for a disturbance in the aging pathway of the autonomic and sensory nerve in the pelvic visceral organs.

収録刊行物

  • Archives of histology and cytology  

    Archives of histology and cytology 69(5), 297-310, 2006-12-31 

    International Society of Histology and Cytology

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各種コード

  • NII論文ID(NAID)
    10018732180
  • NII書誌ID(NCID)
    AA1068990X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09149465
  • データ提供元
    CJP書誌  J-STAGE 
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