Immunohistochemical Evaluation for Hormone Receptors in Breast Cancer: A Practically Useful Evaluation System and Handling Protocol

• Umemura Shinobu

  Department of Pathology, Tokai University School of Medicine

• Kurosumi Masafumi

  Department of Pathology, Saitama Cancer Center

• Moriya Takuya

  Department of Pathology, Tohoku University Hospital

• Oyama Tetsunari

  Department of Pathology, Dokkyo University School of Medicine

• Arihiro Kohji

  Department of Anatomical Pathology, Hiroshima University Hospital

• Yamashita Hiroko

  Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences

• Umekita Yoshihisa

  Department of Pathology, Faculty of Medicine, Kagoshima University

• Komoike Yoshifumi

  Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases

• Shimizu Chikako

  Department of Medical Oncology, National Cancer Center Hospital

• Fukushima Hisaki

  Department of Surgery, Kyorin University School of Medicine

• Kajiwara Hiroshi

  Department of Pathology, Tokai University School of Medicine

• Akiyama Futoshi

  Department of Pathology, Cancer Institute Ariake Hospital

抄録

This article reviews the current status of hormone receptor evaluation in and out of Japan, and introduces the proposed working protocol of the task force for Adequate immunohistochemical evaluation in routine practice for breast cancer by the Japanese Breast Cancer Society. Understanding the principles and the developmental process of immunohistochemisty helps us to utilize a scoring system adequately. Methodologies of hormone receptor examination and immunohistochemical procedures are briefly introduced. Each scoring system is based on different principles. The proposed working protocol takes into account the reproducibility of results among observers, institutions and staining procedures, which is justified based on the current situation in Japan. Future directions for the standardization of immunohistochemical hormone receptor evaluation are also described.

収録刊行物

• Breast Cancer

  Breast Cancer 13 (3), 232-235, 2006

  日本乳癌学会

キーワード

• Hormone receptors
• Immunohistochemistry
• Evaluation system
• Working protocol

詳細情報

• CRID: 1390001204480890624
• NII論文ID: 130004467444
• NII論文ID: 10018769052
• NII書誌ID: AA1103354X
• DOI: 10.2325/jbcs.13.232
• COI: 1:STN:280:DC%2BD28rgsVSqtg%3D%3D
• ISSN: 18804233
• ISSN: 13406868
• PubMed: 16929115
• Web Site: http://www.springerlink.com/index/pdf/10.2325/jbcs.13.232
• Web Site: https://search.jamas.or.jp/link/ui/2007096529
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可