Analysis of Non-Genetic Risk Factors for Adverse Skin Reactions to Radiotherapy among 284 Breast Cancer Patients

• Iwakawa Mayumi

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• Noda Shuhei

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• Yamada Shigeru

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• Yamamoto Naohito

  Chiba Cancer Center

• Miyazawa Yukimasa

  Chiba University Hospital

• Yamazaki Hideya

  Toyonaka Municipal Hospital

• Kawakami Yoshihiro

  Kawakami Breast Thyroid Clinic

• Matsui Yoshifumi

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences Shimizu Kosei General Hospital

• Tsujii Hirohiko

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• Mizoe Junetsu

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• Oda Eisei

  Foundation of Biomedical Research and Innovation Medical Toukei Corporation

• Fukunaga Yukihiro

  Shimizu Kosei General Hospital Dainippon Sumitomo Pharma Co., Ltd

• Imai Takashi

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

抄録

Objectves: We analyzed non-genetic risk factors for adverse skin reactions to irradiation at 4 collaborating Japanese institutions, to design future investigation into genetic risk factors for adverse skin reactions to irradiation in a multicenter setting.<BR>Methods: From April 2001, 284 breast cancer patients, who underwent radiotherapy with breast-conserving surgery, were enrolled from 4 collaborating institutions in Japan. We graded skin reactions according to international scoring systems. Clinical factors were tested against adverse effects.<BR>Results: Grade 1+ skin reactions were observed in 261 (92%) of the patients in less than 3 months, 118 (42%) at 3 months, and 29 (10%) at 6 months in the late phase. Univariate analysis of treatment risk factors (such as the use of a multi-leaf colimeter, wedge-filter, or immobilization device) for skin reactions revealed a significant association (p< 0.0001). After a variable selection procedure with logistic regression, the institution, operative procedure, and magnitude of photon energy remained significantly associated with acute skin reactions. Only the institution was an explanatory variable for skin reactions at 3 and 6 months in the final logistic model.<BR>Conclusion: After stratification, substantial remaining variations in the occurrence of skin reactions of a given level suggested that individual genetic factors contribute markedly to individual radiosensitivity. Analysis of genetic factors associated with adverse effects would be possible by stratifying patients according to institution. Selection of eligible institutions, where appropriate treatment modalities could be performed, would also be possible when planning such a study.

収録刊行物

• Breast Cancer

  Breast Cancer 13 (3), 300-307, 2006

  日本乳癌学会

キーワード

• Radiation therapy
• Adverse effects
• Breast cancer

詳細情報

• CRID: 1390001204480879104
• NII論文ID: 10018769314
• NII書誌ID: AA1103354X
• DOI: 10.2325/jbcs.13.300
• COI: 1:STN:280:DC%2BD28rgsVWjtg%3D%3D
• ISSN: 18804233
• ISSN: 13406868
• Web Site: http://www.springerlink.com/index/pdf/10.2325/jbcs.13.300
• Web Site: https://search.jamas.or.jp/link/ui/2007096539
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可