Histological Features of Intracranial Germinomas Not Disappearing Immediately After Radiotherapy
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- UTSUKI Satoshi
- Department of Neurosurgery, Kitasato University School of Medicine
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- OKA Hidehiro
- Department of Neurosurgery, Kitasato University School of Medicine
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- TANIZAKI Yoshinori
- Department of Neurosurgery, Kitasato University School of Medicine
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- KONDO Koji
- Department of Neurosurgery, Kitasato University School of Medicine
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- KAWANO Nobuyuki
- Isobe Clinic
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- FUJII Kiyotaka
- Department of Neurosurgery, Kitasato University School of Medicine
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Abstract
The histological features of germinomas were investigated to differentiate tumors which completely disappear immediately after irradiation and those that persist. Eighteen previously untreated patients underwent germinoma biopsy and irradiation or combined irradiation and chemotherapy. Four tumors were located only in the pineal gland, eight in the suprasellar region, two in multiple locations, one in the basal ganglia, and three in other regions. Histologically, the germinomas could be divided into type A found in 13 cases which consisted mainly of large neoplastic cells and small lymphocytes, the so-called two-cell pattern, and type B found in five cases which consisted predominantly of fibrous tissue and granulomatous reaction containing occasional neoplastic cells. Follow-up computed tomography or magnetic resonance imaging showed the enhanced mass lesion disappeared in all cases of type A germinomas within 1 month after treatment, but persisted in all cases of type B germinomas for at least 1 month. Type B tumors required up to 12 months to show complete radiographic resolution. Persistent germinomas consisted predominantly of fibrous tissue and granulomatous reaction containing occasional neoplastic cells.<br>
Journal
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 46 (9), 429-433, 2006
The Japan Neurosurgical Society
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Details 詳細情報について
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- CRID
- 1390001205052555136
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- NII Article ID
- 10018769762
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- NII Book ID
- AN00358613
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- ISSN
- 13498029
- 04708105
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed