臍帯血移植後のサイトメガロウイルス反応性T細胞の獲得 Rapid reconstitution of cytomegalovirus-specific CD4^+ T-cells following cord blood transplantation

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著者

    • 高橋 聡 TAKAHASHI Satoshi
    • 東京大学附属病院・内科 Division of Molecular Therapy of the Advanced Clinical Research Center, The University of Tokyo (IMSUT)
    • 三鶴 亜矢子 MITSURU Ayako
    • 東京大学細胞プロセッシング Division of Cell Processing, The Institute of Medical Science, The University of Tokyo (IMSUT)
    • 高橋 圭介 TAKAHASHI Keisuke
    • 東京大学附属病院・内科 Division of Molecular Therapy of the Advanced Clinical Research Center, The University of Tokyo (IMSUT)
    • 大井 淳 OOI Jun
    • 東京大学附属病院・内科 Division of Molecular Therapy of the Advanced Clinical Research Center, The University of Tokyo (IMSUT)
    • 友成 章 TOMONARI Akira
    • 東京大学附属病院・内科 Division of Molecular Therapy of the Advanced Clinical Research Center, The University of Tokyo (IMSUT)
    • 小沼 貴晶 KONUMA Takaaki
    • 東京大学附属病院・内科 Division of Molecular Therapy of the Advanced Clinical Research Center, The University of Tokyo (IMSUT)
    • 森 毅彦 MORI Takehiko
    • 慶應義塾大学医学部血液内科 Division of Hematology, Department of Medicine, Keio University School of Medicine
    • 東條 有伸 TOJO Arinobu
    • 東京大学附属病院・内科 Division of Molecular Therapy of the Advanced Clinical Research Center, The University of Tokyo (IMSUT)

抄録

<p>Cord blood transplantation (CBT) frequently can be complicated by cytomegalovirus (CMV) infection, which is required for administration of antiviral chemotherapy. Although the naïve feature of cord blood T-cells were suggested to increase the incidence of CMV infection, the underlying mechanism is not fully elucidated. CMVresponsive T-cells detected by intracellular interferon-gamma (IFN-γ) staining and CMV-specific CD8<sup>+</sup> T- cells detected by MHC class I tetramers were analyzed in healthy adult blood and recipient blood post-CBT.<b> </b>CMV antigenemia was accompanied in thirty-two of thirty-nine recipients (82%) post-CBT. CMV-responsive CD4<sup>+</sup> T-cells were detected in all recipients with CMV antigenemia within 120 days post CBT [first date of CMV- responsive CD4+ T-cell detection, median 41 days, (32-90 days); peak frequencies 18±21 cells/μl, n=22]. In contrast, CMV-responsive CD8<sup>+</sup> T-cells were detected in only 38% of patients with CMV antigenemia with similar frequencies (peak frequencies 18±24 cells/μl, n=8). CMV-responsive CD4<sup>+</sup> T-cells but not CMV responsive CD8<sup>+</sup> T-cells were significantly induced in all recipients with CMV antigenemia. Rapid reconstitution of CMV-responsive CD4<sup>+</sup> T-cells might suppress the progression of CMV disease from CMV antigenemia.</p>

収録刊行物

  • Cytometry research = 日本サイトメトリー学会機関誌

    Cytometry research = 日本サイトメトリー学会機関誌 16(2), 1-9, 2006-09-25

    日本サイトメトリー学会

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