子宮体癌における細胞形態学的所見と相対的核DNA量との関連性に関する基礎的検討 Correlation between cytopathologic findings and relative DNA content of cancer cells in uterine endometrial cancer

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著者

    • 渡部 洋 WATANABE You
    • 近畿大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Kinki University School of Medicine
    • 上田 晴彦 UEDA Haruhiko
    • 近畿大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Kinki University School of Medicine
    • 星合 昊 HOSHIAI Hiroshi
    • 近畿大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Kinki University School of Medicine

抄録

<p>Relative DNA content of tumor cells determined by flowcytometric analysis (DNA ploidy) has been reported as a prognostic factor of solid cancer. However, it is still unknown correlation between morphologic characteristics and DNA ploidy. We have evaluated the cytopathologic findings including area of nucleus, area of nucleolus, number of nucleolus, nuclear/ cytoplasm ratio, and DNA ploidy in 76 patients with uterine endometrial carcinomas. DNA aneuploid was detected in 18 patients (24%), and DNA aneuploid cases exhibited significantly larger nuclear area and area of nucleolus than that of the DNA diploid cases. However, no correlation was seen in nuclear/cytoplasm ratio, and number of nucleolus. Our findings suggest that relative DNA content would be influenced to area of the nucleus and area of the nucleolus.</p>

収録刊行物

  • Cytometry research = 日本サイトメトリー学会機関誌

    Cytometry research = 日本サイトメトリー学会機関誌 16(2), 19-23, 2006-09-25

    日本サイトメトリー学会

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