書誌事項
- タイトル別名
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- Transport system for the biologically active peptides/proteins into mammalian cells with tranporter peptide
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<p>Molecular targeting of hematopoietic malignancies has not been successfully developed because of difficulties in introducing genes of interest into these neoplastic cells. Recently, peptide delivery systems using protein transduction domains (PTD) have attracted attention for possibly overcoming such obstacles in a therapeutic approach. Here, we show the development of a peptide transporter system of maximum utility that can suppress growth of biologically aggressive or intractable leukemia/lymphoma cells. The transporter (Wr- T) has an enlarged hydrophobic pocket consisting of triple tryptophan-rich domains fused with nine D-enantiomer poly-arginines (D-Arg) via proline spacers, which enhance the efficiency of peptide-introduction over previous mechanisms by more than 20 times. Delivering small amounts of p16 (INK4a) functional peptide by Wr-T enables dramatic inhibition of growth of up to 80% in highly aggressive leukemia/lymphomas lacking p16 expression by recovery of their p16 function. Thus, the WR-T system exhibits high-performance cargopeptide delivery and is supposed to be useful for treating hematopoietic malignancies in combination of the p16 peptide. This system may also help treat various tumors by functional peptide selection.</p>
収録刊行物
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- サイトメトリーリサーチ
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サイトメトリーリサーチ 16 (2), 25-32, 2006
日本サイトメトリー学会
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詳細情報 詳細情報について
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- CRID
- 1390001204472336768
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- NII論文ID
- 10018775160
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- NII書誌ID
- AN10356261
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- ISSN
- 24240664
- 09166920
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可