A CASE OF POSTOPERATIVE NEUROLEPTIC MALIGNANT SYNDROME IN A PATIENT WITH IDIOPATHIC PERFORATION OF THE RECTUM

• YAMAKAWA Toshiki

  Department of Surgery, Kagawa Prefectural Central Hospital

• ONODA Yuji

  Department of Surgery, Kagawa Prefectural Central Hospital

• OHASHI Ryuichirou

  Department of Surgery, Kagawa Prefectural Central Hospital

• IZUMI Sadanobu

  Department of Surgery, Kagawa Prefectural Central Hospital

• SUZUKA Ichio

  Department of Surgery, Kagawa Prefectural Central Hospital

• SHIOTA Kunihiko

  Department of Surgery, Kagawa Prefectural Central Hospital

Bibliographic Information

Other Title

• 特発性直腸穿孔術後に発症した悪性症候群の１例

Abstract

The patient was a 38-year-old man who had received medical treatment for hysterical psychosis craniocerebral-trauma epilepsy, and insomnia. On June 8, 2005, a Hartmann's operation was performed with a diagnosis of panperitonitis caused by idiopathic perforation of the rectum. The patient developed intractable high fever, fasciculation and rigidity of the extremities on the 4^th postoperative day, and went into a coma with tremors on the 5^th postoperative day. On the next day, unstable hemodynamics developed and rapidly progressed. He was taken to the ICU after neuroleptic malignant syndrome was suspected due to an increase of CPK to 1, 308IU/l. Dantrolene sodium was then prescribed. On the 8^th postoperative day, a qualitative analysis of the myoglobinuria was positive, and the CPK level rose to 122, 370IU/l. The patient's general condition then gradually improved, and he was moved to the department of internal medicine on the 56 postoperative day.<br> We report a case of a patient with idiopathic perforation of the rectum, whose life was saved by prescribing dantrolene sodium to combat neuroleptic malignant syndrome, a disease with a death rate of about 10%.

Journal

• Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 67 (8), 1828-1831, 2006

  Japan Surgical Association

Keywords

• neuroleptic malignant syndrome
• Dantrolene sodium

Details

• CRID: 1390282679824611968
• NII Article ID: 130003605157
• NII Article ID: 10018785526
• NII Book ID: AA11189709
• DOI: 10.3919/jjsa.67.1828
• ISSN: 18825133
• ISSN: 13452843
• Web Site: http://www.jstage.jst.go.jp/article/ringe1998/67/8/67_8_1828/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007029749
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed