Special Issue of Diagnosis and Treatment of Early Tracheoesophageal Cancer Pathology of Early Esophageal Cancer

  • Ishiguro Shingo
    Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Tsukamoto Yoshitane
    Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Kataoka Tatsuki
    Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Matsumura Makiko
    Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Nishizawa Yasuko
    Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Ishihara Ryu
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

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Other Title
  • 気管食道領域の早期癌の診断と治療  総説  早期食道癌の病理
  • 早期食道癌の病理
  • ソウキ ショクドウガン ノ ビョウリ
  • Pathology of Early Esophageal Cancer

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Abstract

In Japan, the definition of early cancer varies according to each organ. Early cancer of the esophagus is defined as a case in which the invasion depth is within the intra-mucosa, without lymph node metastasis.<br>The majority of cases of early esophageal cancer are macroscopically type 0-II. Type 0-II is subclassified into 0-IIa (mild elevated type), 0-IIb (flat type), and 0-IIc (mild depressed type). The invasion depth of a 0-IIb lesion is in the mucosa (pEP) or in the lamina propria (pLPM). The invasion depth of the majority of 0-IIa lesions are pEP, pLPM, or in the muscularis mucosae (pMM). With some 0-IIc lesions, there is pSM carcinome. In 0-type (elevated type), in some cases the lesion is not beyond the lamina muscularis mucosae.<br>Lymph node metastasis involves few carcinomas of type (pLPM or pLPM). Carcinomas invading the lamina muscularis mucosae (pMM) show lymph node metastasis of around 10%.<br>Some cases of pMM and pSM (sub-mucosal invasion depth under 200mm) are suitable for EMR. Here, the clinical pathologic findings are reviewed.<br>In pathological diagnosis, severe dysplasia according to WHO classification is often diagnosed in Japan as carcinoma in situ.

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