A Child with Non-Herpetic Acute Limbic Encephalitis Affecting the Claustrum and Hippocampus

DOI PubMed 2 Citations 17 References
  • Ishida Hiroshi
    Department of Pediatrics, Osaka City University Graduate School of Medicine
  • Hattori Hideji
    Department of Pediatrics, Osaka City University Graduate School of Medicine
  • Takaura Natsuko
    Department of Clinical Psychology, Osaka City University Graduate School of Human Life Science
  • Yoshida Toshiko
    Department of Pediatrics, Osaka City University Graduate School of Medicine
  • Tanaka Katsuji
    Department of Pediatrics, PL Hospital
  • Otani Sanae
    Department of Pediatrics, Osaka City University Graduate School of Medicine
  • Matsuoka Osamu
    Department of Pediatrics, Osaka City University Graduate School of Medicine
  • Takahashi Yukitoshi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
  • Yamano Tsunekazu
    Department of Pediatrics, Osaka City University Graduate School of Medicine

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Other Title
  • 前障と海馬に病変を認めた非ヘルペス性急性辺縁系脳炎の１小児例

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Abstract

We experienced an 8-year-old-boy with non-herpetic acute limbic encephalitis (NHALE), who developed headache, convulsion, consciousness disturbance, and ataxia following cold like symptoms. Disturbance of short term memory and a change of character were recognized. Myoclonic seizures and generalized tonic clonic convulsions developed, that responded to antiepileptic agents. Although other symptoms resolved spontaneously, short term memory disturbance persisted. Brain MRI demonstrated the lesion involving the bilateral claustrum and right hippocampus. Three months later, the lesion in the claustrum disappeared, but the hippocampus still showed slight hyperintensity on FLAIR image of MRI. Autoantibodies against glutamine receptor were detected in the cerebrospinal fluid and plasma, which suggested the involvement of immunologic disturbances in this disease. In NHALE, many cases have been reported in adults but not in children, and the further attentions should be paid to childhood-onset NHALE.

Journal

  • NO TO HATATSU

    NO TO HATATSU 38 (6), 443-447, 2006

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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