WEEKLY IRINOTECAN PLUS UFT AND ORAL LEUCOVORIN FOR ADVANCED OR RECURRENT COLORECTAL CANCER AS FIRST LINE CHEMOTHERAPY

• ISHIKURA Hisashi

  Department of Surgery Tokushima Red Cross Hospital

• OKITSU Hiroshi

  Department of Surgery Tokushima Red Cross Hospital

• TAKIZAWA Hiromitsu

  Department of Surgery Tokushima Red Cross Hospital

• YUASA Yasuhiro

  Department of Surgery Tokushima Red Cross Hospital

• KUMIHASHI Yuki

  Department of Pharmacy Tokushima Red Cross Hospital

Bibliographic Information

Other Title

• 進行再発大腸癌に対するＣＰＴ‐１１＋ＵＦＴ／経口Ｌｅｕｃｏｖｏｒｉｎ外来化学療法の有用性の検討

Abstract

We evaluated the antitumoral efficacy and safety of CPT-11 60mg/m² (days 1, 8 and 15) combined with UFT (oral combination of tegafur and uracil) 300mg/body/day plus leucovorin (LV) 75mg/body/day (days 1-21) every 4 weeks as first-line chemotherapy of metastatic and advanced colorectal cancer. Nine patients with diagnosis of advanced colorectal cancer were enrolled. Five patients showed PR (Response rate=55.6%). Stable disease was reported in 4 patients (tumor control rate=100%). The most reported grade 3/4 toxicities were fatigue (33.3% of patients). Other G3/4 toxicity were neutropenia (11.1%) and nausea (11.1%). Severe diarrhea was not observed. Weekly CPT-11 plus UFT/LV was found to be effective and safe as first-line chemotherapy for metastatic colorectal cancer.

Journal

• Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 67 (12), 2897-2900, 2006

  Japan Surgical Association

Keywords

• tegafur-uracil
• CPT-11

Details

• CRID: 1390001204849577856
• NII Article ID: 130003604817
• NII Article ID: 10018817812
• NII Book ID: AA11189709
• DOI: 10.3919/jjsa.67.2897
• ISSN: 18825133
• ISSN: 13452843
• Web Site: http://www.jstage.jst.go.jp/article/ringe1998/67/12/67_12_2897/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007111013
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed