書誌事項
- タイトル別名
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- WEEKLY IRINOTECAN PLUS UFT AND ORAL LEUCOVORIN FOR ADVANCED OR RECURRENT COLORECTAL CANCER AS FIRST LINE CHEMOTHERAPY
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We evaluated the antitumoral efficacy and safety of CPT-11 60mg/m2 (days 1, 8 and 15) combined with UFT (oral combination of tegafur and uracil) 300mg/body/day plus leucovorin (LV) 75mg/body/day (days 1-21) every 4 weeks as first-line chemotherapy of metastatic and advanced colorectal cancer. Nine patients with diagnosis of advanced colorectal cancer were enrolled. Five patients showed PR (Response rate=55.6%). Stable disease was reported in 4 patients (tumor control rate=100%). The most reported grade 3/4 toxicities were fatigue (33.3% of patients). Other G3/4 toxicity were neutropenia (11.1%) and nausea (11.1%). Severe diarrhea was not observed. Weekly CPT-11 plus UFT/LV was found to be effective and safe as first-line chemotherapy for metastatic colorectal cancer.
収録刊行物
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- 日本臨床外科学会雑誌
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日本臨床外科学会雑誌 67 (12), 2897-2900, 2006
日本臨床外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204849577856
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- NII論文ID
- 130003604817
- 10018817812
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- NII書誌ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可