注意欠陥 / 多動性障害と動物モデル Attention Deficit/Hyperactivity Disorder (ADHD) and Animal Models

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著者

    • 船橋 新太郎 FUNAHASHI Shintaro
    • 京都大学大学院人間・環境学研究科共生人間学専攻認知・行動科学講座認知科学分野 Department of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University

抄録

ADHD is one of the most prevalent childhood psychiatric disorders and could be explained as a prefrontal dysfunction. Studies suggest that ADHD is related to deficits of dopamine-related functions, because methylphenidate, which is a dopamine transporter inhibitor, is the most effective medication for the treatment of ADHD. The prefrontal cortex is the cortical area where the most strong dopamine innervation is observed. Local acute injection of dopamine-related drugs to the prefrontal cortex produces modulation of task-related activity and behavioral deficits in cognitive task performances. Thus, the dysfunction of dopamine-related modulation in the prefrontal cortex could be a possible candidate of biological causes of ADHD. To prove this idea, in the future we are going to inject 6-OHDA into infant monkeys' prefrontal cortex to disturb dopamine functions chronically and compare its behavior with normal monkeys.

収録刊行物

  • 霊長類研究 = Primate research  

    霊長類研究 = Primate research 22(2), 85-96, 2006-12-20 

    Primate Society of Japan

参考文献:  38件

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各種コード

  • NII論文ID(NAID)
    10018823073
  • NII書誌ID(NCID)
    AN10080557
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09124047
  • NDL 記事登録ID
    8617675
  • NDL 雑誌分類
    ZR4(科学技術--生物学--動物)
  • NDL 請求記号
    Z18-1898
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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