Mebendazole Selective Membrane Sensor and Its Application to Pharmaceutical Analysis

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A PVC membrane sensor for the selective determination of mebendazole (MBZ) was fabricated. The sensor is based on an ion association of MBZ with silicotungstic acid (STA) as ion pair and bis(2-ethylhexyl)phthalate (BEP) as the plasticizing agent in a PVC matrix. The sensor showed a linear response for MBZ for a concentration range 1.0 × 10<sup>-6</sup> - 5.0 × 10<sup>-2</sup> M with a Nernstian slope of 55.8 mV/decade (limit of detection 6.3 × 10<sup>-7</sup> M) in the pH range 4 - 7. It has a fast response time of <30 s. The sensor showed a very good selectivity for MBZ with respect to a large number of ions. The direct determination of MBZ in pharmaceutical formulations gave results that compare well with the data obtained from the standard method.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 23(3), 291-294, 2007-03-10

    The Japan Society for Analytical Chemistry

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各種コード

  • NII論文ID(NAID)
    10018823920
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    8671939
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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