Protein kinase C family as a molecular target for cancer chemotheraphy

• YURA Yoshiaki

  Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry

• HAMADA Masakazu

  Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry

• IWAI Soichi

  Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry

Bibliographic Information

Other Title

• 分子標的としてのプロテインキナーゼＣファミリー
• ブンシ ヒョウテキ ト シテ ノ プロテインキナーゼ Cファミリー

Abstract

Certain protein kinase C (PKC) isoforms expressed in cancer must play important roles in tumor promotion, tumor invasion and resistance to cytotoxic anti-tumor drugs. A variety of PKC inhibitors have been designed and their anti-tumor activities examined in many cancers. Safingol, a PKC a-selective inhibitor, induces endonuclease G-mediated apoptosis of human oral squamous cell carcinoma cells in a caspase-independent manner. Studies of the mechanisms of PKC inhibitors should contribute to the development of molecular targeting therapy for oral cancer.

Journal

• Journal of The Japanese Stomatological Society

  Journal of The Japanese Stomatological Society 55 (2), 104-107, 2006

  Japanese Stomatological Society

Keywords

• Molecular targeting therapy
• Protein kinase C
• Apoptosis

Details

• CRID: 1390001206434898688
• NII Article ID: 10018827351
• NII Article ID: 130004335933
• NII Book ID: AN00189050
• DOI: 10.11277/stomatology1952.55.104
• ISSN: 21850461
• ISSN: 00290297
• NDL BIB ID: 7924331
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7924331
• Web Site: https://search.jamas.or.jp/link/ui/2006185756
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed