Study of intrafamilial transmission of Helicobacter pylori infection in Japanese children

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  • SUGIURA Hiroki
    The Nippon Dental University, Graduate School at Niigata, Course of Clinical Stomatology, Oral and Maxillofacial Surgery and Systemic Medicine
  • YAMAGUCHI Akira
    The Nippon Dental University, Graduate School at Niigata, Course of Clinical Stomatology, Oral and Maxillofacial Surgery and Systemic Medicine
  • SHIBASA Koichi
    The Nippon Dental University, Graduate School at Niigata, Course of Clinical Stomatology, Oral and Maxillofacial Surgery and Systemic Medicine

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  • 小児におけるＨｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉ　ＤＮＡの検出からみた感染経路の検討
  • ショウニ ニ オケル Helicobacter pylori DNA ノ ケンシュツ カラ ミタ カンセン ケイロ ノ ケントウ

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Abstract

Introduction: Helicobacter pylori (H. pylori) DNA has been detected at a high prevalence in saliva. The aim of this study was to clarify the prevalence and the risk of intrafamilial transmission of H. pylori infection by detecting H. pylori DNA in saliva of Japanese children and their parents.<BR>Materials & Methods: Saliva was collected from 92 children and their parents, and nested PCR and PCRRFLP were used to detect and analyze H. pylori DNA. Subtyping by PCR-RFLP is considered to be useful in order to clarify the mode of transmission.<BR>Results: The detection rate of H. pylori DNA in saliva was 12.0%(11/92) in Japanese children, however, all of the children aged less than 6 years old were negative. All of the H.pylori infected children had H.pylori positive parents (both or only one), and in 7 out of 11 cases, children and their parents were infected with the sam e strain. Especially, in 6 cases, the subtype of both the child and the mother was the same.<BR>Conclusion: H. pylori DNA in saliva was detected in 12.0%, and parents-to-child, especially mother-to-child, transmission is the most likely route of intrafamilial infection of H. pylori.

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