A case of giant lymphoproliferative disorder with submandibular localization

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  • SUEMATSU Motoo
    Division of Dentistry and Oral Surgery, Matsubara Tokushukai Hospital
  • KISHINO Mitsunobu
    Department of Oral Pathology, Osaka University Graduate School of Dentistry
  • TAKEUCHI Noritami
    Division of Dentistry and Oral Surgery, Toyonaka Municipal Hospital
  • TAKASE Toshiyuki
    Division of Dentistry and Oral Surgery, Toyonaka Municipal Hospital
  • KANESAKI Tomohiko
    Second Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry
  • NAKAZAWA Mitsuhiro
    Second Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry

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Other Title
  • 顎下部に発生した巨大リンパ節増殖症の１例
  • ガク カブ ニ ハッセイ シタ キョダイ リンパセツ ゾウショクショウ ノ 1レイ

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Abstract

We describe a case of giant lymphoproliferative disorder in the submandibular region. A 52-year-old male had a unicentric, unusually large, slow growing, asymptomatic mass which involved aggregation of plural lymph nodes. A pre-operative definite diagnosis was difficult as routine investigations, ultrasound sonography, CT, MRI, and RI scintigraphy were inconclusive. A biopsy specimen was characterized by only reactive follicular hyperplasia of lymph nodes without hyalinized and hypervascular germinal centers or plasma cell aggregates that are common features of Castleman's disease. Surgical removal of lymph nodes was performed and there have been no signs of recurrence.

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