DNA Conformational Switching by Use of an Intercalator and Its Receptor

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著者

    • NISHIMURA Tomoki
    • Department of Chemical Processes & Environments, Faculty of Environmental Engineering, The University of Kitakyushu
    • TAKEDA Yoichi
    • Department of Chemical Processes & Environments, Faculty of Environmental Engineering, The University of Kitakyushu
    • SHIMADA Naohiko
    • Department of Chemical Processes & Environments, Faculty of Environmental Engineering, The University of Kitakyushu
    • SAKURAI Kazuo
    • Department of Chemical Processes & Environments, Faculty of Environmental Engineering, The University of Kitakyushu

抄録

DNA conformational switching between B and Z forms was controlled with tilorone (intercalator) and sulfocalix[8]arene (C8AS, receptor for tilorone). When tilorone was added to the <I>Z</I>-DNA that had been beforehand induced by cobalt hexamine, the conformational transition from Z to B form was induced. The resultant <I>B</I>-DNA was turned back to <I>Z</I>-DNA by adding C8AS. This change was a clear-cut transition because most of the intercalated tilorone molecules were pulled out and captured by C8AS. This mechanism was established by isothermal titration calorimetry in which the binding constant of tilorone to C8AS was shown twice larger than that of tilorone/DNA.

収録刊行物

  • Chemistry letters  

    Chemistry letters 36(3), 388-389, 2007-03-05 

    The Chemical Society of Japan

参考文献:  12件

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各種コード

  • NII論文ID(NAID)
    10018829506
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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